Mrs. X kidnaps J.J. and forces him to solve an enigma; Joshua and Katie reconnect; George is held prisoner on a plane that spirals out of control.
Stephanie's boosted superspeed results in her traveling to the near-future where she sees the Powells captured by the government when their powers become public knowledge. Back in the present, Stephanie tries to stop the events she's seen from occurring.
The Powells' lives are in danger when a super-villain with animal-like powers is tasked by Mrs. X to eliminate the family. Meanwhile, good girl Daphne takes a rebellious step by ditching school with boyfriend Chris to attend a Sara Bareilles music video shoot; JJ becomes suspicious of Mr. Litchfield's motives when he's presented with different equations...
The mysterious Mrs. X tasks the sexy - and dangerous - Sophie to cause Jim and George to fall under her spell and make them do whatever she wants them to - which could place Jim's marriage in jeopardy. Meanwhile, Stephanie must decide whether or not to inject a patient with the trilsettum serum and risk turning him into a super in order to retain Dr. King's trust
Jim's feelings of guilt are overwhelming when, during a fight with a thug, he diverts a bullet that accidentally hits a boy - causing life-threatening harm. Meanwhile, Daphne's boyfriend, Chris, steals the trilsettum serum from the Powell house and injects his wheelchair-bound father, Roy (Anthony Michael Hall), with disastrous results.
The Powells' lives are in danger when Dr. King orders shape-shifter Victoria Morrow to infiltrate the household and murder one of the family members; and JJ, with the aid of Daphne, attempts to solve the cold case murder of his ex-girlfriend Natalie's mother.