Michael Chiklis as James "Jim" Powell, Sr. – a police sketch artist who is super-strong, nearly invulnerable, can leap over tall buildings, and is fire-resistant. When in contact with cinoxate, his powers fail. His weakness lies in finesse and agility.

Julie Benz as Stephanie Powell – a scientist who works at Global Tech. She has super speed(running 10 miles in just under 5 seconds) and an incredibly fast metabolism that allows her to heal quickly. She got stabbed by Lucas Winnick, a man with claws, and she was dying. Stephanie got injected with the trilsettum serum, which made her run faster than the speed of light. This makes her able to time travel. She was initially working on the research of the Trilsetum Coronis, the "crown jewel" plant of the Amazon Basin. She later found out that the plant shared the same chromosomes as the families' super powered DNA.

Kay Panabaker as Daphne Nicole Powell – Jim and Stephanie's 16-year-old daughter. She has the power of telepathy and the ability to see the memories of others by touching them, which has allowed her to restore her own memories. She later found out that she can also change a person's mind through telepathic push.She finds out that she can erase memories in episode 19.

Jimmy Bennett as James "JJ" Powell, Jr. – Jim and Stephanie's 14-year-old son; a teenager with vast intelligence. He has the ability to speed-read and comprehend large amounts of information by just reading the page (but is only capable of remembering it for six hours). He is also capable of learning a new language fluently in a matter of minutes. His powers extend to a form of "genius vision". When he becomes sexually aroused, his powers fail. He can also perceive an opponent's weakest spot to strike. In episode 15, it is revealed that he is immune to Daphne's telepathic push.